More on acne therapy with systemic retinoids
نویسندگان
چکیده
منابع مشابه
Why Topical Retinoids Are Mainstay of Therapy for Acne
Acne-focused dermatology expert groups have consistently recommended that most patients with acne be treated with a combination of topical retinoid and antimicrobial therapy. This is based on clinical data as well as evidence that these drug classes have different and complementary mechanisms of action that target multiple aspects of acne's complex pathophysiology. Recent evidence-based guideli...
متن کاملAcne and Systemic Diseases
Acne is a very common, multifactorial, complex, and chronic disease of the pilosebaceous unit that affects approximately 85% of adolescent patients and 3% of adult patients. The roles of sebaceous glands, androgens, follicular epithelial cells, Propionibacterium acnes, immune mediators, environmental factors, and genetic factors are well known in acne pathogenesis. Although it is not a life-thr...
متن کاملIs less more with isotretinoin and acne?
Evidence • Three RCTs compared conventional with low dosing. -For 24 weeks, 60 patients with moderate acne used low (0.25 to 0.4 mg/kg daily) or conventional doses (0.5 to 0.7 mg/kg daily).1 The low-dose group showed equivalent efficacy (acne grading and lesion counts); increased patient satisfaction (76% very satisfied vs 31%); and a higher (non-significant) 1-year relapse rate (18% vs 13%). -...
متن کاملSystemic therapy with immunosuppressive agents and retinoids in hidradenitis suppurativa: a systematic review.
Hidradenitis suppurativa (HS) is a difficult disease to treat. Although the pathogenesis of this inflammatory skin disease is largely unknown, the important role of the immune system has been demonstrated in both experimental and clinical studies. Clinicians are therefore increasingly prescribing systemic treatments with immunosuppressive agents, but the more traditionally used systemic retinoi...
متن کاملOral retinoids in the treatment of seborrhoea and acne.
Isotretinoin is an extremely effective drug if given systemically in severe forms of seborrhoea and acne, being the only retinoid with potent sebostatic properties. Its unique activity on the sebaceous gland still remains unclear since isotretinoin barely binds to cellular retinoic-acid-binding proteins and to retinoic acid receptors. Its bioavailability is approximately 25% and can be increase...
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ژورنال
عنوان ژورنال: Medical Council
سال: 2018
ISSN: 2079-701X
DOI: 10.21518/2079-701x-2018-12-128-130